Harnessing Nanomedicine to Potentiate the Chemo-Immunotherapeutic Effects of Doxorubicin and Alendronate Co-Encapsulated in Pegylated Liposomes

• Main Authors: Alberto Gabizon (Author), Hilary Shmeeda (Author), Benjamin Draper (Author), Ana Parente-Pereira (Author), John Maher (Author), Amaia Carrascal-Miniño (Author), Rafael T. M. de Rosales (Author), Ninh M. La-Beck (Author)
• Format: Book
• Published: MDPI AG, 2023-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Encapsulation of Doxorubicin (Dox), a potent cytotoxic agent and immunogenic cell death inducer, in pegylated (Stealth) liposomes, is well known to have major pharmacologic advantages over treatment with free Dox. Reformulation of alendronate (Ald), a potent amino-bisphosphonate, by encapsulation in...