Vectofusin-1, a New Viral Entry Enhancer, Strongly Promotes Lentiviral Transduction of Human Hematopoietic Stem Cells

• Autori principali: David Fenard (Autore), Dina Ingrao (Autore), Ababacar Seye (Autore), Julien Buisset (Autore), Sandrine Genries (Autore), Samia Martin (Autore), Antoine Kichler (Autore), Anne Galy (Autore)
• Natura: Libro
• Pubblicazione: Elsevier, 2013-01-01T00:00:00Z.
• Soggetti: article
• Accesso online: Connect to this object online.

Gene transfer into hCD34+ hematopoietic stem/progenitor cells (HSCs) using human immunodeficiency virus type 1 (HIV-1)-based lentiviral vectors (LVs) has several promising therapeutic applications. Yet, efficiency, safety, and cost of LV gene therapy could be ameliorated by enhancing target cell tra...