Structural Characterization of Co-Crystals of Chlordiazepoxide with <i>p</i>-Aminobenzoic Acid and Lorazepam with Nicotinamide by DSC, X-ray Diffraction, FTIR and Raman Spectroscopy

• मुख्य लेखकों: Patrycja Garbacz (लेखक), Dominik Paukszta (लेखक), Artur Sikorski (लेखक), Marek Wesolowski (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: MDPI AG, 2020-07-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

The low water solubility of benzodiazepines seriously affects their bioavailability and, in consequence, their biological activity. Since co-crystallization has been found to be a promising way to modify undesirable properties in active pharmaceutical ingredients, the objective of this study was to...