Mutations at opposite ends of the DIII/S4-S5 linker of sodium channel Na_V1.7 produce distinct pain disorders

• मुख्य लेखकों: Tyrrell Lynda (लेखक), Dib-Hajj Sulayman D (लेखक), Cheng Xiaoyang (लेखक), Wright Dowain A (लेखक), Fischer Tanya Z (लेखक), Waxman Stephen G (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: SAGE Publishing, 2010-04-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

<p>Abstract</p> <p>Background</p> <p>Two groups of gain-of-function mutations in sodium channel Na_V1.7, which are expressed in dorsal root ganglion (DRG) neurons, produce two clinically-distinct pain syndromes - inherited erythromelalgia (IEM) and...