Nutritionally physiological cell culture medium and 3D culture influence breast tumour proteomics and anti-cancer drug effectiveness

• Hauptverfasser: Xiaodan Zhang (Verfasst von), Tianhong Cheng (Verfasst von), Ellie Cho (Verfasst von), Wenjia Lu (Verfasst von), Delphine Denoyer (Verfasst von), Paul McMillan (Verfasst von), Kalyan Shobhana (Verfasst von), Swati Varshney (Verfasst von), Nicholas A. Williamson (Verfasst von), Alastair Stewart (Verfasst von)
• Format: Buch
• Veröffentlicht: Elsevier, 2024-12-01T00:00:00Z.
• Schlagworte: article
• Online-Zugang: Connect to this object online.

Many drugs have been discontinued during phase II/III breast cancer clinical trials due to lack of clinical efficacy, indicating shortcomings in predictive value of preclinical data. Nutrient availability in the tumour cell microenvironment and the dimensionality of in vitro tumour cells likely impa...