Discovery of novel conjugates of quinoline and thiazolidinone urea as potential anti-colorectal cancer agent

• Автори: Li Xiong (Автор), Huan He (Автор), Mengmeng Fan (Автор), Liping Hu (Автор), Fei Wang (Автор), Xiaomeng Song (Автор), Shengmin Shi (Автор), Baohui Qi (Автор)
• Формат: Книга
• Опубліковано: Taylor & Francis Group, 2022-12-01T00:00:00Z.
• Предмети: article
• Онлайн доступ: Connect to this object online.

Based on the obtained SARs, further structural optimisation of compound BC2021-104511-15i was conducted in this investigation, and totally ten novel quinoline derivates were designed, synthesised and optimised for biological activity. Among them, compound 10a displayed significant in vitro anticance...