Discovery of novel conjugates of quinoline and thiazolidinone urea as potential anti-colorectal cancer agent

• Main Authors: Li Xiong (Author), Huan He (Author), Mengmeng Fan (Author), Liping Hu (Author), Fei Wang (Author), Xiaomeng Song (Author), Shengmin Shi (Author), Baohui Qi (Author)
• Format: Book
• Published: Taylor & Francis Group, 2022-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Based on the obtained SARs, further structural optimisation of compound BC2021-104511-15i was conducted in this investigation, and totally ten novel quinoline derivates were designed, synthesised and optimised for biological activity. Among them, compound 10a displayed significant in vitro anticance...