Selective miRNA Modulation Fails to Activate HIV Replication in In Vitro Latency Models

• Main Authors: María Rosa López-Huertas (Author), Matías Morín (Author), Nadia Madrid-Elena (Author), Carolina Gutiérrez (Author), Laura Jiménez-Tormo (Author), Javier Santoyo (Author), Francisco Sanz-Rodríguez (Author), Miguel Ángel Moreno Pelayo (Author), Laura García Bermejo (Author), Santiago Moreno (Author)
• Format: Book
• Published: Elsevier, 2019-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

HIV remains incurable because of viral persistence in latent reservoirs that are inaccessible to antiretroviral therapy. A potential curative strategy is to reactivate viral gene expression in latently infected cells. However, no drug so far has proven to be successful in vivo in reducing the reserv...