Selective miRNA Modulation Fails to Activate HIV Replication in In Vitro Latency Models

• Autores principales: María Rosa López-Huertas (Autor), Matías Morín (Autor), Nadia Madrid-Elena (Autor), Carolina Gutiérrez (Autor), Laura Jiménez-Tormo (Autor), Javier Santoyo (Autor), Francisco Sanz-Rodríguez (Autor), Miguel Ángel Moreno Pelayo (Autor), Laura García Bermejo (Autor), Santiago Moreno (Autor)
• Formato: Libro
• Publicado: Elsevier, 2019-09-01T00:00:00Z.
• Materias: article
• Acceso en línea: Connect to this object online.

HIV remains incurable because of viral persistence in latent reservoirs that are inaccessible to antiretroviral therapy. A potential curative strategy is to reactivate viral gene expression in latently infected cells. However, no drug so far has proven to be successful in vivo in reducing the reserv...