Strategic use of levofolinic acid for methotrexate-induced side effects in juvenile idiopathic arthritis: a prospective observational study

• Main Authors: Giorgia Martini (Author), Alessandra Meneghel (Author), Michele Fastiggi (Author), Filippo Dell'Apa (Author), Fabio Vittadello (Author), Francesco Zulian (Author)
• Format: Book
• Published: BMC, 2023-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Objective To evaluate the efficacy of levofolinic acid (LVF) administered 48 h before methotrexate (MTX) in reducing gastrointestinal side effects without interference with drug efficacy. Methods A prospective observational study was performed including patients with Juvenile Idiopathic Art...