Self-assembling protein nanocarrier for selective delivery of cytotoxic polypeptides to CXCR4+ head and neck squamous cell carcinoma tumors

• Main Authors: Elisa Rioja-Blanco (Author), Irene Arroyo-Solera (Author), Patricia Álamo (Author), Isolda Casanova (Author), Alberto Gallardo (Author), Ugutz Unzueta (Author), Naroa Serna (Author), Laura Sánchez-García (Author), Miquel Quer (Author), Antonio Villaverde (Author), Esther Vázquez (Author), Ramon Mangues (Author), Lorena Alba-Castellón (Author), Xavier León (Author)
• Format: Book
• Published: Elsevier, 2022-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Loco-regional recurrences and distant metastases represent the main cause of head and neck squamous cell carcinoma (HNSCC) mortality. The overexpression of chemokine receptor 4 (CXCR4) in HNSCC primary tumors associates with higher risk of developing loco-regional recurrences and distant metastases,...