Aggressive uveal melanoma displays a high degree of centrosome amplification, opening the door to therapeutic intervention

• Autori principali: Dorota Sabat‐Pośpiech (Autore), Kim Fabian‐Kolpanowicz (Autore), Helen Kalirai (Autore), Natalie Kipling (Autore), Sarah E Coupland (Autore), Judy M Coulson (Autore), Andrew B Fielding (Autore)
• Natura: Libro
• Pubblicazione: Wiley, 2022-07-01T00:00:00Z.
• Soggetti: article
• Accesso online: Connect to this object online.

Abstract Uveal melanoma (UM) is the most common intraocular cancer in adults. Whilst treatment of primary UM (PUM) is often successful, around 50% of patients develop metastatic disease with poor outcomes, linked to chromosome 3 loss (monosomy 3, M3). Advances in understanding UM cell biology may in...