Aggressive uveal melanoma displays a high degree of centrosome amplification, opening the door to therapeutic intervention

• Main Authors: Dorota Sabat‐Pośpiech (Author), Kim Fabian‐Kolpanowicz (Author), Helen Kalirai (Author), Natalie Kipling (Author), Sarah E Coupland (Author), Judy M Coulson (Author), Andrew B Fielding (Author)
• Format: Book
• Published: Wiley, 2022-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Uveal melanoma (UM) is the most common intraocular cancer in adults. Whilst treatment of primary UM (PUM) is often successful, around 50% of patients develop metastatic disease with poor outcomes, linked to chromosome 3 loss (monosomy 3, M3). Advances in understanding UM cell biology may in...