Heme Cytotoxicity And The Pathogenesis of Immune Mediated Inflammatory Diseases.

• Main Authors: Rasmus eLarsen (Author), Zélia eGouveia (Author), Miguel P Soares (Author), Raffaella eGozzelino (Author)
• Format: Book
• Published: Frontiers Media S.A., 2012-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Heme, iron (Fe) protoporphyrin IX, functions as a prosthetic group in a range of hemoproteins essential to support life under aerobic conditions. The Fe contained within the prosthetic heme groups of these hemoproteins can catalyze the production of cytotoxic reactive oxygen species (ROS). Presumabl...