Treating Cancer by Targeting Telomeres and Telomerase

• Main Authors: Marko Ivancich (Author), Zachary Schrank (Author), Luke Wojdyla (Author), Brandon Leviskas (Author), Adijan Kuckovic (Author), Ankita Sanjali (Author), Neelu Puri (Author)
• Format: Book
• Published: MDPI AG, 2017-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Telomerase is expressed in more than 85% of cancer cells. Tumor cells with metastatic potential may have a high telomerase activity, allowing cells to escape from the inhibition of cell proliferation due to shortened telomeres. Human telomerase primarily consists of two main components: hTERT, a cat...