Nitric oxide synthase inhibition decreases tolerance to hyperoxia in newborn rats

• Main Authors: M. R. Pierce (Author), C. A. Voelker (Author), I. R. S. Sosenko (Author), S. Bustamante (Author), S. M. Olister (Author), X.-J. Zhang (Author), D. A. Clark (Author), M. J. S. Miller (Author)
• Format: Book
• Published: Hindawi Limited, 1995-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

We evaluated the effects of sustained perinatal inhibition of NO synthase (NOS) on hyperoxia induced lung injury in newborn rats. NG-nitro-Larginine-methyl-ester (L-NAME) or untreated water was administered to pregnant rats for the final 7 days of gestation and during lactation; followed by postnata...