Solubility Improvement of Benexate through Salt Formation Using Artificial Sweetener

• Main Authors: Okky Dwichandra Putra (Author), Daiki Umeda (Author), Eriko Fujita (Author), Tamami Haraguchi (Author), Takahiro Uchida (Author), Etsuo Yonemochi (Author), Hidehiro Uekusa (Author)
• Format: Book
• Published: MDPI AG, 2018-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Benexate, a drug used clinically as a defensive type anti-ulcer agent, has poor solubility and a bitter taste. To improve its solubility, a crystal engineering approach was proposed with the formation of novel salts using an artificial sweetener as a salt co-former. This was also expected to address...