The Aptamer Ob2, a novel AChE inhibitor, restores cognitive deficits and alleviates amyloidogenesis in 5×FAD transgenic mice

• Үндсэн зохиолчид: Zhiman Liang (Зохиогч), Xin Li (Зохиогч), Xiaoting Luo (Зохиогч), Hongjie Luo (Зохиогч), Yajun Chen (Зохиогч), Mingliang Cai (Зохиогч), Xinxin Zhong (Зохиогч), Yingying Fang (Зохиогч), Ting Guo (Зохиогч), Yusheng Shi (Зохиогч), Xingmei Zhang (Зохиогч)
• Формат: Ном
• Хэвлэсэн: Elsevier, 2022-06-01T00:00:00Z.
• Нөхцлүүд: article
• Онлайн хандалт: Connect to this object online.

Loss of cerebral cholinergic neurons and decreased levels of acetylcholine (ACh) are considered to be major factors causing cognitive dysfunction in Alzheimer's disease (AD). Abnormally elevated levels of acetylcholinesterase (AChE) resulting in decreased levels of ACh are common in AD patients...