The Aptamer Ob2, a novel AChE inhibitor, restores cognitive deficits and alleviates amyloidogenesis in 5×FAD transgenic mice

• Main Authors: Zhiman Liang (Author), Xin Li (Author), Xiaoting Luo (Author), Hongjie Luo (Author), Yajun Chen (Author), Mingliang Cai (Author), Xinxin Zhong (Author), Yingying Fang (Author), Ting Guo (Author), Yusheng Shi (Author), Xingmei Zhang (Author)
• Format: Book
• Published: Elsevier, 2022-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Loss of cerebral cholinergic neurons and decreased levels of acetylcholine (ACh) are considered to be major factors causing cognitive dysfunction in Alzheimer's disease (AD). Abnormally elevated levels of acetylcholinesterase (AChE) resulting in decreased levels of ACh are common in AD patients...