TIGIT/CD226 Axis Regulates Anti-Tumor Immunity

• Main Authors: Jinah Yeo (Author), Minkyung Ko (Author), Dong-Hee Lee (Author), Yoon Park (Author), Hyung-seung Jin (Author)
• Format: Book
• Published: MDPI AG, 2021-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Tumors escape immune surveillance by inducing various immunosuppressive pathways, including the activation of inhibitory receptors on tumor-infiltrating T cells. While monoclonal antibodies (mAbs) blocking programmed cell death 1 (PD-1), programmed death-ligand 1 (PD-L1), and cytotoxic T lymphocyte-...