Addition of Endothelin A-Receptor Blockade Spoils the Beneficial Effect of Combined Renin-Angiotensin and Soluble Epoxide Hydrolase Inhibition: Studies on the Course of Chronic Kidney Disease in 5/6 Nephrectomized Ren-2 Transgenic Hypertensive Rats

• Váldodahkkit: Věra Čertíková Chábová (Dahkki), Petr Kujal (Dahkki), Zdeňka Vaňourková (Dahkki), Petra Škaroupková (Dahkki), Janusz Sadowski (Dahkki), Elzbieta Kompanowska-Jezierska (Dahkki), Vladimír Tesař (Dahkki), Bruce Hammock (Dahkki), John Imig (Dahkki), Hana Maxová (Dahkki), Luděk Červenka (Dahkki), Ivana Vaněčková (Dahkki)
• Materiálatiipa: Girji
• Almmustuhtton: Karger Publishers, 2019-11-01T00:00:00Z.
• Fáttát: article
• Liŋkkat: Connect to this object online.

Introduction: Previous studies in Ren-2 transgenic hypertensive rats (TGR) after 5/6 renal ablation (5/6 NX) have shown that besides pharmacological blockade of the renin-angiotensin system (RAS) also increasing kidney tissue epoxyeicosatrienoic acids (EET) levels by blocking soluble epoxide hydrola...