Addition of Endothelin A-Receptor Blockade Spoils the Beneficial Effect of Combined Renin-Angiotensin and Soluble Epoxide Hydrolase Inhibition: Studies on the Course of Chronic Kidney Disease in 5/6 Nephrectomized Ren-2 Transgenic Hypertensive Rats

• Main Authors: Věra Čertíková Chábová (Author), Petr Kujal (Author), Zdeňka Vaňourková (Author), Petra Škaroupková (Author), Janusz Sadowski (Author), Elzbieta Kompanowska-Jezierska (Author), Vladimír Tesař (Author), Bruce Hammock (Author), John Imig (Author), Hana Maxová (Author), Luděk Červenka (Author), Ivana Vaněčková (Author)
• Format: Book
• Published: Karger Publishers, 2019-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Introduction: Previous studies in Ren-2 transgenic hypertensive rats (TGR) after 5/6 renal ablation (5/6 NX) have shown that besides pharmacological blockade of the renin-angiotensin system (RAS) also increasing kidney tissue epoxyeicosatrienoic acids (EET) levels by blocking soluble epoxide hydrola...