Astragaloside IV Alleviates Tacrolimus-Induced Chronic Nephrotoxicity via p62-Keap1-Nrf2 Pathway

• Główni autorzy: Ping Gao (Autor), Xiaoyi Du (Autor), Lili Liu (Autor), Hua Xu (Autor), Maochang Liu (Autor), Xinlei Guan (Autor), Chengliang Zhang (Autor)
• Format: Książka
• Wydane: Frontiers Media S.A., 2021-01-01T00:00:00Z.
• Hasła przedmiotowe: article
• Dostęp online: Connect to this object online.

Tacrolimus-induced chronic nephrotoxicity (TIN) hinders its long-term use in patients. However, there are no drugs available in the clinic to relieve it at present. Astragaloside IV (AS-IV) is a saponin extract of the Astragalus which is widely used in the treatment of kidney disease. This study aim...