Astragaloside IV Alleviates Tacrolimus-Induced Chronic Nephrotoxicity via p62-Keap1-Nrf2 Pathway

• Autori principali: Ping Gao (Autore), Xiaoyi Du (Autore), Lili Liu (Autore), Hua Xu (Autore), Maochang Liu (Autore), Xinlei Guan (Autore), Chengliang Zhang (Autore)
• Natura: Libro
• Pubblicazione: Frontiers Media S.A., 2021-01-01T00:00:00Z.
• Soggetti: article
• Accesso online: Connect to this object online.

Tacrolimus-induced chronic nephrotoxicity (TIN) hinders its long-term use in patients. However, there are no drugs available in the clinic to relieve it at present. Astragaloside IV (AS-IV) is a saponin extract of the Astragalus which is widely used in the treatment of kidney disease. This study aim...