Antiepileptic Effects of Single and Repeated Oral Administrations of S-312-d, a Novel Calcium Channel Antagonist, on Tonic Convulsions in Spontaneously Epileptic Rats

• Main Authors: Taku Amano (Author), Zhu Aihua (Author), Hiroaki Matsubayashi (Author), Takahiro Seki (Author), Tadao Serikawa (Author), Masashi Sasa (Author), Norio Sakai (Author)
• Format: Book
• Published: Elsevier, 2004-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

We investigated the effects of single and repeated administrations of S-312-d (methyl-4,7-dihydro-3-isobutyl-6-methyl-4-(3-nitrophenyl)-thieno-[2,3-b]pyridine-5-carboxylate), a newly synthesized L-type Ca2+-channel blocker, on tonic convulsions and absence-like seizures in the spontaneously epilepti...