Acquired Drug Resistance Enhances Imidazoquinoline Efflux by P-Glycoprotein

• Main Authors: Anunay J. Pulukuri (Author), Anthony J. Burt (Author), Larissa K. Opp (Author), Colin M. McDowell (Author), Maryam Davaritouchaee (Author), Amy E. Nielsen (Author), Rock J. Mancini (Author)
• Format: Book
• Published: MDPI AG, 2021-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Multidrug-Resistant (MDR) cancers attenuate chemotherapeutic efficacy through drug efflux, a process that transports drugs from within a cell to the extracellular space via ABC (ATP-Binding Cassette) transporters, including P-glycoprotein 1 (P-gp or ABCB1/MDR1). Conversely, Toll-Like Receptor (TLR)...