Acquired Drug Resistance Enhances Imidazoquinoline Efflux by P-Glycoprotein

• Glavni autori: Anunay J. Pulukuri (Autor), Anthony J. Burt (Autor), Larissa K. Opp (Autor), Colin M. McDowell (Autor), Maryam Davaritouchaee (Autor), Amy E. Nielsen (Autor), Rock J. Mancini (Autor)
• Format: Knjiga
• Izdano: MDPI AG, 2021-12-01T00:00:00Z.
• Teme: article
• Online pristup: Connect to this object online.

Multidrug-Resistant (MDR) cancers attenuate chemotherapeutic efficacy through drug efflux, a process that transports drugs from within a cell to the extracellular space via ABC (ATP-Binding Cassette) transporters, including P-glycoprotein 1 (P-gp or ABCB1/MDR1). Conversely, Toll-Like Receptor (TLR)...