Acquired Drug Resistance Enhances Imidazoquinoline Efflux by P-Glycoprotein

• Váldodahkkit: Anunay J. Pulukuri (Dahkki), Anthony J. Burt (Dahkki), Larissa K. Opp (Dahkki), Colin M. McDowell (Dahkki), Maryam Davaritouchaee (Dahkki), Amy E. Nielsen (Dahkki), Rock J. Mancini (Dahkki)
• Materiálatiipa: Girji
• Almmustuhtton: MDPI AG, 2021-12-01T00:00:00Z.
• Fáttát: article
• Liŋkkat: Connect to this object online.

Multidrug-Resistant (MDR) cancers attenuate chemotherapeutic efficacy through drug efflux, a process that transports drugs from within a cell to the extracellular space via ABC (ATP-Binding Cassette) transporters, including P-glycoprotein 1 (P-gp or ABCB1/MDR1). Conversely, Toll-Like Receptor (TLR)...