A Brain-Penetrating Hsp90 Inhibitor NXD30001 Inhibits Glioblastoma as a Monotherapy or in Combination With Radiation

• Autores principales: Hao Chen (Autor), Yuanying Gong (Autor), Yufang Ma (Autor), Reid C. Thompson (Autor), Jialiang Wang (Autor), Zhixiang Cheng (Autor), Lixia Xue (Autor)
• Formato: Libro
• Publicado: Frontiers Media S.A., 2020-06-01T00:00:00Z.
• Materias: article
• Acceso en línea: Connect to this object online.

Glioblastoma multiforme (GBM) is a highly heterogeneous disease, which is initiated and sustained by various molecular alterations in an array of signal transduction pathways. Heat-shock protein 90 (Hsp90) is a molecular chaperone and is critically implicated in folding and activation of a diverse g...