Judicious Toggling of mTOR Activity to Combat Insulin Resistance and Cancer: Current Evidence and Perspectives

• मुख्य लेखकों: Pei Shi Ong (लेखक), Louis Z Wang (लेखक), Xiaoyun Dai (लेखक), Sheng Hsuan Tseng (लेखक), Shang Jun Loo (लेखक), Gautam Sethi (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: Frontiers Media S.A., 2016-10-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

The mechanistic target of rapamycin (mTOR), via its two distinct multiprotein complexes, mTORC1 and mTORC2, plays a central role in the regulation of cellular growth, metabolism and migration. A dysregulation of the mTOR pathway has in turn been implicated in several pathological conditions includin...