Judicious Toggling of mTOR Activity to Combat Insulin Resistance and Cancer: Current Evidence and Perspectives

• Main Authors: Pei Shi Ong (Author), Louis Z Wang (Author), Xiaoyun Dai (Author), Sheng Hsuan Tseng (Author), Shang Jun Loo (Author), Gautam Sethi (Author)
• Format: Book
• Published: Frontiers Media S.A., 2016-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The mechanistic target of rapamycin (mTOR), via its two distinct multiprotein complexes, mTORC1 and mTORC2, plays a central role in the regulation of cellular growth, metabolism and migration. A dysregulation of the mTOR pathway has in turn been implicated in several pathological conditions includin...