Single-cell analysis of the survival mechanisms of fratricidal CAR-T targeting of T cell malignancies

• Autori principali: Hui Hu (Autore), Ling Tang (Autore), Yuyan Zhao (Autore), Jiali Cheng (Autore), Mei Huang (Autore), Yong You (Autore), Ping Zou (Autore), Qian Lei (Autore), Xiaojian Zhu (Autore), An-Yuan Guo (Autore)
• Natura: Libro
• Pubblicazione: Elsevier, 2024-06-01T00:00:00Z.
• Soggetti: article
• Accesso online: Connect to this object online.

Chimeric antigen receptor T (CAR-T) cell therapy targeting T cell tumors still faces many challenges, one of which is its fratricide due to the target gene expressed on CAR-T cells. Despite this, these CAR-T cells can be expanded in vitro by extending the culture time and effectively eliminating mal...