Single-cell analysis of the survival mechanisms of fratricidal CAR-T targeting of T cell malignancies
Chimeric antigen receptor T (CAR-T) cell therapy targeting T cell tumors still faces many challenges, one of which is its fratricide due to the target gene expressed on CAR-T cells. Despite this, these CAR-T cells can be expanded in vitro by extending the culture time and effectively eliminating mal...
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Elsevier,
2024-06-01T00:00:00Z.
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