Single-cell analysis of the survival mechanisms of fratricidal CAR-T targeting of T cell malignancies

• Main Authors: Hui Hu (Author), Ling Tang (Author), Yuyan Zhao (Author), Jiali Cheng (Author), Mei Huang (Author), Yong You (Author), Ping Zou (Author), Qian Lei (Author), Xiaojian Zhu (Author), An-Yuan Guo (Author)
• Format: Book
• Published: Elsevier, 2024-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Chimeric antigen receptor T (CAR-T) cell therapy targeting T cell tumors still faces many challenges, one of which is its fratricide due to the target gene expressed on CAR-T cells. Despite this, these CAR-T cells can be expanded in vitro by extending the culture time and effectively eliminating mal...