Separating clinical antibodies from repertoire antibodies, a path to in silico developability assessment

• Main Authors: Christopher Negron (Author), Joyce Fang (Author), Michael J. McPherson (Author), W. Blaine Stine (Author), Andrew J. McCluskey (Author)
• Format: Book
• Published: Taylor & Francis Group, 2022-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Approaches for antibody discovery have seen substantial improvement and success in recent years. Yet, advancing antibodies into the clinic remains difficult because therapeutic developability concerns are challenging to predict. We developed a computational model to simplify antibody developability...