Separating clinical antibodies from repertoire antibodies, a path to in silico developability assessment

• Những tác giả chính: Christopher Negron (Tác giả), Joyce Fang (Tác giả), Michael J. McPherson (Tác giả), W. Blaine Stine (Tác giả), Andrew J. McCluskey (Tác giả)
• Định dạng: Sách
• Được phát hành: Taylor & Francis Group, 2022-12-01T00:00:00Z.
• Những chủ đề: article
• Truy cập trực tuyến: Connect to this object online.

Approaches for antibody discovery have seen substantial improvement and success in recent years. Yet, advancing antibodies into the clinic remains difficult because therapeutic developability concerns are challenging to predict. We developed a computational model to simplify antibody developability...