An artificial neural network−pharmacokinetic model and its interpretation using Shapley additive explanations

• প্রধান লেখক: Chika Ogami (লেখক), Yasuhiro Tsuji (লেখক), Hiroto Seki (লেখক), Hideaki Kawano (লেখক), Hideto To (লেখক), Yoshiaki Matsumoto (লেখক), Hiroyuki Hosono (লেখক)
• বিন্যাস: গ্রন্থ
• প্রকাশিত: Wiley, 2021-07-01T00:00:00Z.
• বিষয়গুলি: article
• অনলাইন ব্যবহার করুন: Connect to this object online.

Abstract We developed a method to apply artificial neural networks (ANNs) for predicting time‐series pharmacokinetics (PKs), and an interpretable the ANN‐PK model, which can explain the evidence of prediction by applying Shapley additive explanations (SHAP). A previous population PK (PopPK) model of...