An artificial neural network−pharmacokinetic model and its interpretation using Shapley additive explanations

• Автори: Chika Ogami (Автор), Yasuhiro Tsuji (Автор), Hiroto Seki (Автор), Hideaki Kawano (Автор), Hideto To (Автор), Yoshiaki Matsumoto (Автор), Hiroyuki Hosono (Автор)
• Формат: Книга
• Опубліковано: Wiley, 2021-07-01T00:00:00Z.
• Предмети: article
• Онлайн доступ: Connect to this object online.

Abstract We developed a method to apply artificial neural networks (ANNs) for predicting time‐series pharmacokinetics (PKs), and an interpretable the ANN‐PK model, which can explain the evidence of prediction by applying Shapley additive explanations (SHAP). A previous population PK (PopPK) model of...