Identification of a Key Amino Acid of the Human 5-HT2B Serotonin Receptor Important for Sarpogrelate Binding

• Main Authors: Habib Abul Muntasir (Author), Murad Hossain (Author), Mohiuddin Ahmed Bhuiyan (Author), Tadazumi Komiyama (Author), Takashi Nakamura (Author), Masanobu Ozaki (Author), Takafumi Nagatomo (Author)
• Format: Book
• Published: Elsevier, 2007-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Based on radio-ligand binding and molecular modeling studies, sarpogrelate shows a moderate selectivity for 5-HT2B versus 5-HT2A receptors. To confirm the modeling data of sarpogrelate to 5-HT2B receptors predicting interaction of sarpogrelate towards Asp135 in helix 3 of 5-HT2B receptors, we constr...