Identification of a Key Amino Acid of the Human 5-HT2B Serotonin Receptor Important for Sarpogrelate Binding

• Autores principales: Habib Abul Muntasir (Autor), Murad Hossain (Autor), Mohiuddin Ahmed Bhuiyan (Autor), Tadazumi Komiyama (Autor), Takashi Nakamura (Autor), Masanobu Ozaki (Autor), Takafumi Nagatomo (Autor)
• Formato: Libro
• Publicado: Elsevier, 2007-01-01T00:00:00Z.
• Materias: article
• Acceso en línea: Connect to this object online.

Based on radio-ligand binding and molecular modeling studies, sarpogrelate shows a moderate selectivity for 5-HT2B versus 5-HT2A receptors. To confirm the modeling data of sarpogrelate to 5-HT2B receptors predicting interaction of sarpogrelate towards Asp135 in helix 3 of 5-HT2B receptors, we constr...