Atractylenolide-I covalently binds to CYP11B2, selectively inhibits aldosterone synthesis, and improves hyperaldosteronism

• Váldodahkkit: Wenjuan Liu (Dahkki), Zhenqiang Li (Dahkki), Simeng Chu (Dahkki), Xiaoyao Ma (Dahkki), Xiaoying Wang (Dahkki), Min Jiang (Dahkki), Gang Bai (Dahkki)
• Materiálatiipa: Girji
• Almmustuhtton: Elsevier, 2022-01-01T00:00:00Z.
• Fáttát: article
• Liŋkkat: Connect to this object online.

Hyperaldosteronism is a common disease that is closely related to endocrine hypertension and other cardiovascular diseases. Cytochrome P450 11B2 (CYP11B2), an important enzyme in aldosterone (ALD) synthesis, is a promising target for the treatment of hyperaldosteronism. However, selective inhibitors...