Atractylenolide-I covalently binds to CYP11B2, selectively inhibits aldosterone synthesis, and improves hyperaldosteronism

• Autores principales: Wenjuan Liu (Autor), Zhenqiang Li (Autor), Simeng Chu (Autor), Xiaoyao Ma (Autor), Xiaoying Wang (Autor), Min Jiang (Autor), Gang Bai (Autor)
• Formato: Libro
• Publicado: Elsevier, 2022-01-01T00:00:00Z.
• Materias: article
• Acceso en línea: Connect to this object online.

Hyperaldosteronism is a common disease that is closely related to endocrine hypertension and other cardiovascular diseases. Cytochrome P450 11B2 (CYP11B2), an important enzyme in aldosterone (ALD) synthesis, is a promising target for the treatment of hyperaldosteronism. However, selective inhibitors...