Block of Voltage-Gated Sodium Channels as a Potential Novel Anti-cancer Mechanism of TIC10

• Main Authors: Eva Fuchs (Author), David Alexander Christian Messerer (Author), Georg Karpel-Massler (Author), Michael Fauler (Author), Thomas Zimmer (Author), Bettina Jungwirth (Author), Karl Josef Föhr (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: Tumor therapeutics are aimed to affect tumor cells selectively while sparing healthy ones. For this purpose, a huge variety of different drugs are in use. Recently, also blockers of voltage-gated sodium channels (VGSCs) have been recognized to possess potentially beneficial effects in tu...