Disruption of Proteostasis by Natural Products and Synthetic Compounds That Induce Pervasive Unfolding of Proteins: Therapeutic Implications
Exposure of many cancer cells, including multiple myeloma cells, to cytotoxic concentrations of natural products celastrol and withaferin A or synthetic compounds of the IHSF series resulted in denaturation of a luciferase reporter protein. Proteomic analysis of detergent-insoluble extract fractions...
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| Main Authors: | , , , , , , |
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| Format: | Book |
| Published: |
MDPI AG,
2023-04-01T00:00:00Z.
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| Online Access: | Connect to this object online. |
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