The phenylpropionamide extract of hemp (Cannabis sativa L.) seed improves learning memory ability and survival rate by attenuating microglia activation and reducing amyloid deposition via the SIRT1-AMAD10 pathway in APP/PS1 mice

• Main Authors: Mei Yang (Author), Jianbo Ji (Author), Siqing Bu (Author), Jieyue Sun (Author), Yue Zhang (Author), Xiaoyan Hu (Author), Jiaozhen Zhang (Author), Hongxiang Lou (Author), Peihong Fan (Author)
• Format: Book
• Published: Elsevier, 2024-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: Fructus cannabis (Hemp seed), the dried and mature fruit of Cannabis sativa L., was reported to have effects against Alzheimer's disease (AD) in different experimental models. However, either chemical composition or mechanisms of action was not clear. Our previous work isolated and...