The phenylpropionamide extract of hemp (Cannabis sativa L.) seed improves learning memory ability and survival rate by attenuating microglia activation and reducing amyloid deposition via the SIRT1-AMAD10 pathway in APP/PS1 mice

• المؤلفون الرئيسيون: Mei Yang (مؤلف), Jianbo Ji (مؤلف), Siqing Bu (مؤلف), Jieyue Sun (مؤلف), Yue Zhang (مؤلف), Xiaoyan Hu (مؤلف), Jiaozhen Zhang (مؤلف), Hongxiang Lou (مؤلف), Peihong Fan (مؤلف)
• التنسيق: كتاب
• منشور في: Elsevier, 2024-08-01T00:00:00Z.
• الموضوعات: article
• الوصول للمادة أونلاين: Connect to this object online.

Background: Fructus cannabis (Hemp seed), the dried and mature fruit of Cannabis sativa L., was reported to have effects against Alzheimer's disease (AD) in different experimental models. However, either chemical composition or mechanisms of action was not clear. Our previous work isolated and...