Simultaneous determination of ivabradine and N-desmethylivabradine in human plasma and urine using a LC-MS/MS method: application to a pharmacokinetic study

• Hoofdauteurs: Chengtao Lu (Auteur), Yanyan Jia (Auteur), Jing Yang (Auteur), Xin Jin (Auteur), Ying Song (Auteur), Wenxing Liu (Auteur), Yi Ding (Auteur), Xiaoli Sun (Auteur), Aidong Wen (Auteur)
• Formaat: Boek
• Gepubliceerd in: Elsevier, 2012-04-01T00:00:00Z.
• Onderwerpen: article
• Online toegang: Connect to this object online.

A sensitive and specific liquid-chromatography tandem mass spectrometry (LC-MS/MS) assay has been developed and validated for the simultaneous quantification of ivabradine and its active metabolite N-desmethylivabradine in human plasma and urine. The assay employed a single liquid-liquid extraction...