Simultaneous determination of ivabradine and N-desmethylivabradine in human plasma and urine using a LC-MS/MS method: application to a pharmacokinetic study

• Main Authors: Chengtao Lu (Author), Yanyan Jia (Author), Jing Yang (Author), Xin Jin (Author), Ying Song (Author), Wenxing Liu (Author), Yi Ding (Author), Xiaoli Sun (Author), Aidong Wen (Author)
• Format: Book
• Published: Elsevier, 2012-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

A sensitive and specific liquid-chromatography tandem mass spectrometry (LC-MS/MS) assay has been developed and validated for the simultaneous quantification of ivabradine and its active metabolite N-desmethylivabradine in human plasma and urine. The assay employed a single liquid-liquid extraction...