Simultaneous determination of ivabradine and N-desmethylivabradine in human plasma and urine using a LC-MS/MS method: application to a pharmacokinetic study

• 主要な著者: Chengtao Lu (著者), Yanyan Jia (著者), Jing Yang (著者), Xin Jin (著者), Ying Song (著者), Wenxing Liu (著者), Yi Ding (著者), Xiaoli Sun (著者), Aidong Wen (著者)
• フォーマット: 図書
• 出版事項: Elsevier, 2012-04-01T00:00:00Z.
• 主題: article
• オンライン･アクセス: Connect to this object online.

A sensitive and specific liquid-chromatography tandem mass spectrometry (LC-MS/MS) assay has been developed and validated for the simultaneous quantification of ivabradine and its active metabolite N-desmethylivabradine in human plasma and urine. The assay employed a single liquid-liquid extraction...