Treatment with a Catalytic Superoxide Dismutase (SOD) Mimetic Improves Liver Steatosis, Insulin Sensitivity, and Inflammation in Obesity-Induced Type 2 Diabetes

• Main Authors: Gina M. Coudriet (Author), Meghan M. Delmastro-Greenwood (Author), Dana M. Previte (Author), Meghan L. Marré (Author), Erin C. O'Connor (Author), Elizabeth A. Novak (Author), Garret Vincent (Author), Kevin P. Mollen (Author), Sojin Lee (Author), H. Henry Dong (Author), Jon D. Piganelli (Author)
• Format: Book
• Published: MDPI AG, 2017-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Oxidative stress and persistent inflammation are exaggerated through chronic over-nutrition and a sedentary lifestyle, resulting in insulin resistance. In type 2 diabetes (T2D), impaired insulin signaling leads to hyperglycemia and long-term complications, including metabolic liver dysfunction, resu...