Protein PEGylation for the design of biobetters: from reaction to purification processes

• Auteurs principaux: João Henrique Picado Madalena Santos (Auteur), Karin Mariana Torres-Obreque (Auteur), Giovanna Pastore Meneguetti (Auteur), Beatriz Panichi Amaro (Auteur), Carlota Oliveira Rangel-Yagui (Auteur)
• Format: Livre
• Publié: Universidade de São Paulo, 2018-11-01T00:00:00Z.
• Sujets: article
• Accès en ligne: Connect to this object online.

The covalent attachment of polyethylene glycol (PEG) to therapeutical proteins is an important route to develop biobetters for biomedical, biotech and pharmaceutical industries. PEG conjugation can shield antigenic epitopes of the protein, reduce degradation by proteolytic enzymes, enhance long-term...