CRISPR-mediated activation of autism gene Itgb3 restores cortical network excitability via mGluR5 signaling

• 主要な著者: Fanny Jaudon (著者), Agnes Thalhammer (著者), Lorena Zentilin (著者), Lorenzo A. Cingolani (著者)
• フォーマット: 図書
• 出版事項: Elsevier, 2022-09-01T00:00:00Z.
• 主題: article
• オンライン･アクセス: Connect to this object online.

Many mutations in autism spectrum disorder (ASD) affect a single allele, indicating a key role for gene dosage in ASD susceptibility. Recently, haplo-insufficiency of ITGB3, the gene encoding the extracellular matrix receptor β3 integrin, was associated with ASD. Accordingly, Itgb3 knockout (KO) mic...