CRISPR-mediated activation of autism gene Itgb3 restores cortical network excitability via mGluR5 signaling

• Asıl Yazarlar: Fanny Jaudon (Yazar), Agnes Thalhammer (Yazar), Lorena Zentilin (Yazar), Lorenzo A. Cingolani (Yazar)
• Materyal Türü: Kitap
• Baskı/Yayın Bilgisi: Elsevier, 2022-09-01T00:00:00Z.
• Konular: article
• Online Erişim: Connect to this object online.

Many mutations in autism spectrum disorder (ASD) affect a single allele, indicating a key role for gene dosage in ASD susceptibility. Recently, haplo-insufficiency of ITGB3, the gene encoding the extracellular matrix receptor β3 integrin, was associated with ASD. Accordingly, Itgb3 knockout (KO) mic...