CRISPR-mediated activation of autism gene Itgb3 restores cortical network excitability via mGluR5 signaling

• Autori principali: Fanny Jaudon (Autore), Agnes Thalhammer (Autore), Lorena Zentilin (Autore), Lorenzo A. Cingolani (Autore)
• Natura: Libro
• Pubblicazione: Elsevier, 2022-09-01T00:00:00Z.
• Soggetti: article
• Accesso online: Connect to this object online.

Many mutations in autism spectrum disorder (ASD) affect a single allele, indicating a key role for gene dosage in ASD susceptibility. Recently, haplo-insufficiency of ITGB3, the gene encoding the extracellular matrix receptor β3 integrin, was associated with ASD. Accordingly, Itgb3 knockout (KO) mic...