Sphingosine-1-Phosphate Alleviates Irradiation Induced Salivary Gland Hypofunction through Preserving Endothelial Cells and Resident Macrophages

• मुख्य लेखकों: Tao Yang (लेखक), Qingguo Zhao (लेखक), Meijun Hu (लेखक), Simin Pan (लेखक), Linying Zhang (लेखक), Ruoxi Zhu (लेखक), Bowen Zhou (लेखक), Xuanhe Feng (लेखक), Zhenhua Gao (लेखक), Zhao Zhu (लेखक), Yu Zhang (लेखक), Liang Hu (लेखक), Fei Liu (लेखक), Zhaochen Shan (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: MDPI AG, 2022-10-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

Radiotherapy for head-and-neck cancers frequently causes long-term hypofunction of salivary glands that severely compromises quality of life and is difficult to treat. Here, we studied effects and mechanisms of Sphingosine-1-phosphate (S1P), a versatile signaling sphingolipid, in preventing irrevers...