Sphingosine-1-Phosphate Alleviates Irradiation Induced Salivary Gland Hypofunction through Preserving Endothelial Cells and Resident Macrophages

• Main Authors: Tao Yang (Author), Qingguo Zhao (Author), Meijun Hu (Author), Simin Pan (Author), Linying Zhang (Author), Ruoxi Zhu (Author), Bowen Zhou (Author), Xuanhe Feng (Author), Zhenhua Gao (Author), Zhao Zhu (Author), Yu Zhang (Author), Liang Hu (Author), Fei Liu (Author), Zhaochen Shan (Author)
• Format: Book
• Published: MDPI AG, 2022-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Radiotherapy for head-and-neck cancers frequently causes long-term hypofunction of salivary glands that severely compromises quality of life and is difficult to treat. Here, we studied effects and mechanisms of Sphingosine-1-phosphate (S1P), a versatile signaling sphingolipid, in preventing irrevers...